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Journal: Frontiers in Neurology
Article Title: Assessing the value of oligoclonal band count in multiple sclerosis: insights from a large cohort analysis
doi: 10.3389/fneur.2026.1719470
Figure Lengend Snippet: Box plots illustrating (a) the number of CSF-specific oligoclonal bands (OCB) of OCB positive persons with MS and CIS, (b) intrathecal produced amount of IgG of persons with MS and CIS with detectable IgG-synthesis, according to Reiber’s diagram, and (c) KFLC index of all persons with MS and CIS with KFLC index >6.1. Panel (d) shows OCB count cross across different clinical presentation types. Boxes represent interquartile range with horizontal line within the box representing the median. Lower and upper whiskers represent min. and max. values. MS, multiple sclerosis; CIS, clinically isolated syndrome; OCB, oligoclonal bands; CSF, cerebrospinal fluid; IgG, immunoglobulin G; KFLC, kappa free light chains.
Article Snippet: Serum and CSF concentrations of KFLC were measured using nephelometry with the
Techniques: Produced, Isolation
Journal: Frontiers in Neurology
Article Title: Assessing the value of oligoclonal band count in multiple sclerosis: insights from a large cohort analysis
doi: 10.3389/fneur.2026.1719470
Figure Lengend Snippet: Receiver operating characteristic (ROC) curves for the differentiation of MS and CIS ( n = 269). The plot illustrates the diagnostic accuracy of OCB count, KFLC index, intrathecal IgG synthesis according to Reiber, and the combination of OCB count and KFLC index. The area under the curve (AUC) with corresponding 95% confidence interval (CI) for each methodology is indicated in the legend. The distinct inflection point in the intrathecal IgG curve reflects the high proportion of individuals with a calculated IgG synthesis of 0.0 mg/L, where the methodology reaches its limit of continuous discrimination. MS, multiple sclerosis; CIS, clinically isolated syndrome; OCB, oligoclonal bands; KFLC, kappa free light chain; IgG, immunoglobulin G.
Article Snippet: Serum and CSF concentrations of KFLC were measured using nephelometry with the
Techniques: Diagnostic Assay, Isolation
Journal: Frontiers in Neurology
Article Title: Assessing the value of oligoclonal band count in multiple sclerosis: insights from a large cohort analysis
doi: 10.3389/fneur.2026.1719470
Figure Lengend Snippet: Scatter plots showing the positive correlations between the number of oligoclonal bands (OCB) in CSF with (a) intrathecal IgG levels (rho = 0.6963, p < 0.0001) and (b) KFLC index (rho = 0.7099, p < 0.0001). MS, multiple sclerosis; OCB, oligoclonal bands; CSF, cerebrospinal fluid; KFLC, kappa free light chains; EDSS, IgG, immunoglobulin G.
Article Snippet: Serum and CSF concentrations of KFLC were measured using nephelometry with the
Techniques:
Journal: Journal of Mass Spectrometry and Advances in the Clinical Lab
Article Title: A non-affinity-dependent high-resolution mass spectrometry method for detecting and typing monoclonal free light immunoglobulin chains
doi: 10.1016/j.jmsacl.2025.11.004
Figure Lengend Snippet: Filled and unfilled circles represent samples with and without mFLC according to HRMS. The position of the circle in the graph represents im-FLC concentrations of the sample (x-axis: lambda and y-axis: kappa). The shaded area in the graph represents a position corresponding to the absence of mFLC according to im-FLC. The non-shaded area in the graph represents a position corresponding to the presence of mFLC according to im-FLC.
Article Snippet: Blood was drawn into tubes with a gel separator and clot activator, allowed to clot for at least 30 min, and centrifuged within 4 h. Thereafter, S-FLC was measured using a particle-enhanced nephelometric immunoassay with N Latex FLC kappa and
Techniques: